Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 to 16th november 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The determination was carried out using a procedure designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance

Test material

Constituent 1
Chemical structure
Reference substance name:
(±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
EC Number:
276-851-9
EC Name:
(±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
Cas Number:
72797-41-2
Molecular formula:
C21H25ClN2O4S
IUPAC Name:
7-({6-chloro-10-methyl-9,9-dioxo-9λ⁶-thia-10-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}amino)heptanoic acid
Test material form:
solid: crystalline
Details on test material:
White powder
Specific details on test material used for the study:
Batch : 18114773

Results and discussion

Vapour pressure
Key result
Temp.:
ca. 25 °C
Vapour pressure:
< 0.001 Pa

Any other information on results incl. tables

Recorded temperatures, mass differences and the resulting calculated values of vapor pressure are shown in the joint document FV36PL.

A total of 5 runs were completed for the main sequence. The values of vapor pressure at 25 °C has

been extrapolated from each graph. (see tables of the FV36PL document).

Applicant's summary and conclusion

Conclusions:
The vapor pressure of the test item has been determined to be less than 9.8 x 10-4 Pa at 25 ºC.
Executive summary:

The vapor pressure of 1574 ACIDE CRIST has been determined to be less than 9.8 x 10-4 Pa at 25 °C, using the vapor pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.