Registration Dossier
Registration Dossier
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EC number: 204-527-9 | CAS number: 122-19-0
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 17, 2017 to October 17, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181: Solubility in organic solvents
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identity: Benzyldimethyl(octadecyl)ammonium chloride
Batch no: 14217
Appearance: White to off white solid
Composition: Benzyldimethyl(octadecyl)ammonium chloride
Content: Cationic activity 97.6%
Expiry date: 06/2019
Storage conditions: Room temperature, in dark, in closed vessel - Key result
- Medium:
- n-octanol
- Solubility:
- ca. 133 - ca. 160 g/L
- Temp.:
- 20.3 °C
- Conclusions:
- Under study conditions, the n-octanol solubility of the test substance, C18 ADBAC, was determined to be in range of 133-160 g/L.
- Executive summary:
A study was conducted to determine the n-octanol solubility of the test substance, C18 ADBAC (active: 97.6%) at 20˚C, according to CIPAC MT 181 (solubility in organic solvents). The solubility of the test substance was found to be <200-100 g/L in a preliminary test at room temperature. Therefore, the main test was conducted and the n-octanol solubility was determined to range from 133 -160 g/L (Wannenwetsch, 2018).
Reference
Preliminary test:
| organic solvent | Amount (g) | Volume (mL) | Temperature (˚C) | Solubility range (g/L) | Amount for main test (g) |
| n-octanol | 0.1024 | 10 | 20 | 200-100 | 0.4 |
Main test:
| organic solvent | Amount (g) | Volume (mL) | Temperature (˚C) | Solubility range (g/L) |
| n-octanol | 0.4018 | 3 | 20 | 133-160 |
| n-octanol | 0.4011 | 3 | 20 | 133-160 |
Description of key information
The n-octanol solubility of the test substance was determined according to CIPAC MT 181: solubility in organic solvents (Wannenwetsch, 2018).
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 160 g/L
Additional information
n-octanol solubility was determined to range from 133 -160 g/L. As a conservative approach, the upper value has been considered further for hazard/risk assessment.
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