Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Study design

Analytical method:
other: UPLC-MS

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
0.8
Temp.:
20 °C
pH:
7
Type:
log Pow
Partition coefficient:
0.19
Remarks on result:
other: calculation method
Remarks:
pH and temperature not recorded
Details on results:
The substance appears to react with water and produce dimers and therefore a range of Log Pow values was recorded. The value for the monomer (substance as such) is included as the key value.

Applicant's summary and conclusion

Conclusions:
The HPLC method was used to determine the Log Pow of the substance. The log Pow is 0.8 for the test substance.