Registration Dossier
Registration Dossier
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EC number: 200-463-0 | CAS number: 60-23-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Mercaptamine
- EC Number:
- 200-463-0
- EC Name:
- Mercaptamine
- Cas Number:
- 60-23-1
- Molecular formula:
- C2H7NS
- IUPAC Name:
- mercaptamine
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- other: UPLC-MS
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- 0.8
- Temp.:
- 20 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- 0.19
- Remarks on result:
- other: calculation method
- Remarks:
- pH and temperature not recorded
- Details on results:
- The substance appears to react with water and produce dimers and therefore a range of Log Pow values was recorded. The value for the monomer (substance as such) is included as the key value.
Applicant's summary and conclusion
- Conclusions:
- The HPLC method was used to determine the Log Pow of the substance. The log Pow is 0.8 for the test substance.
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