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EC number: 207-005-9
CAS number: 421-50-1
Measurement of the density of 1,1,1 -trifluoroacetone was performed
using a volumetric flask according to standardised guidelines (OECD TG
109, EU A.3 and OPPTS 830.7300) under GLP conditions.
The test item is a volatile liquid with a boiling temperature of 20.5°C.
It was observed that te density of the test item could not be
experimentally determined at 20°C due to significant evaporation (gas
bubbles) at about 19°C. The density of the test item was determined at a
lower constant temperature of about 6°C.
The density of 1,1,1-trifluoroacetone at 6ºC ± 1°C was 1.23 g/cm3.
Degradation in Percentage of the Theoretical Maximum IC Production
n.a.: Not applicable
Evaluation of the readily biodegradability of 1,1,1-trifluoroacetone was
performed in an aerobic, aqueous inoculated medium (Headspace Test)
according to standardised guidelines (OECD TG 310) under GLP conditions.
The test item was added to the mineral medium to give a final organic
carbon concentration of 20 mg C/L, corresponding with 62.3 mg test
item/L. Since 1,1,1-trifluoroacetone was volatile, aliquots of 5.6 µL
were added directly to each vessel by injection through the septum,
using a glass Hamilton GC syringe, corresponding with 6.7 mg test
item/vessel of 107 mL.
The test consisted of five groups:
1. Test item: vessels each containing 1,1,1-trifluoroacetone (CAS NR :
421-50-1) at 20 mg C/L,
2. Toxicity control: vessels each containing 1,1,1-trifluoroacetone (CAS
NR : 421-50-1) at 20 mg C/L and reference item at 20 mg C/L,
3. Positive control: vessels each containing reference item at 20 mg C/L,
4. Blank control: vessels containing untreated mineral medium.
5. Abiotic control: vessels containing 1,1,1-trifluoroacetone (CAS NR :
421-50-1) at 20 mg C/L and mineral medium treated with sterilizing agent.
The CO2 evolution resulting from the aerobic biodegradation of the test
item was determined by measuring the inorganic carbon (IC) produced in
the test vessels in excess of that produced in blank vessels containing
inoculated medium only. Biodegradation was expressed as a percentage of
the theoretical maximum IC production, based on the quantity of test
item (as C) initially added.
The relative biodegradation values calculated from the measurements
performed during the test period revealed no significant biodegradation
of 1,1,1-trifluoroacetone (CAS NR : 421-50-1). Since all criteria for
acceptability of the test were met, this study was considered to be
Therefore, under the conditions of the Headspace Test, 1,1,1
-trifluoroacetone was not readily biodegradable.
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