Registration Dossier

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
explosiveness, other
Type of information:
other: Expert assessment
Adequacy of study:
key study
Study period:
January 30, 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This assessment is based on an examination of the molecular structure of 2-butoxyethyl methacrylate and relevant regulation.
Qualifier:
no guideline followed
Principles of method if other than guideline:
An evaluation was undertaken to determine the explosiveness of 2-butoxyethyl methacrylate. Structural assessment of 2-butoxyethyl methacrylate and its minor constituents was achieved in reference to relevant regulation, namely the Classification, Labelling, and Packaging (CLP) Regulation (EC) No 1272/2008, and information outlined in Table A6.1 of Appendix 6, UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed. that details a number of structural motifs that are indicative of explosive behaviour in organic material.
GLP compliance:
no
Key result
Test series:
other: Not relevant
Method:
other: Expert assessment
Parameter:
other: Explosiveness
Result:
result is considered "-" (negative)
Remarks on result:
other: 2-Butoxyethyl methacrylate is not expected to possess explosive properties

Assessment of 2-butoxyethyl methacrylate for functionality typically associated with explosive properties:

Functional Group

Conclusions

C-C unsaturation

C-C unsaturation present; however, these are not contained in functional groups typically associated with explosive behaviour

C-metal, N-metal

Not present

Contiguous nitrogen atoms

Not present

Contiguous oxygen atoms

Not present

N-O

Not present

N-halogen

Not present

O-halogen

Not present

Interpretation of results:
GHS criteria not met
Conclusions:
According to the assessment for 2-butoxyethyl methacrylate and its minor constituents, the registered substance is not expected to exhibit explosive behaviour due to a lack of structural features associated with explosiveness. Classification as an explosive material is not required (CLP Regulation (EC) No 1272/2008).
Executive summary:

An evaluation of the molecular structure of 2-butoxyethyl methacrylate and its minor constituents was undertaken to establish whether the registered substance contained explosive properties. CLP Regulation (EC) No 1272/2008 was referred to in order to establish a screening-style procedure, as well as the UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed. (Appendix 6), which outlines structural motifs typical of organic material known to give rise to explosive behaviour. The identification of functional groups in 2-butoxyethyl methacrylate that are associated with explosiveness, such as C-C unsaturation (acetylenes, acetylides, 1,2-dienes), C-metal and N-metal (Grignard reagents, organo-lithium compounds), and contiguous N atoms (azides, aliphatic azo compounds, diazonium salts, hydrazines, will reliably signal explosive potential.

2-Butoxyethyl methacrylate does not to contain any halogens, nitrogen, or metals. Oxygen is present within the structure of 2-butoxyethyl methacrylate and its minor constituents, however, the oxygen atoms are not present within chemical groups considered to be associated with explosive properties. C-C unsaturation is present in 2-butoxyethyl methacrylate (i.e. the alkene of the methacrylate group) and in 4-hydroxyanisole present as an aromatic ring, but these functional groups are not considered to confer explosive properties.

As a consequence of this assessment, it can be concluded that 2-butoxyethyl methacrylate and its minor constituents are not expected to possess explosive potential and, therefore, the registered substance does not require classification as an explosive material (CLP Regulation (EC) No 1272/2008). 

Description of key information

Given a lack of identified structural features that are typically linked with explosive behaviour, it has been concluded that 2-butoxyethyl methacrylate is not expected to exhibit explosiveness. Classification under CLP Regulation (EC) No 1272/2008 as an explosive material is not required.

Key value for chemical safety assessment

Explosiveness:
non explosive

Additional information

A Klimisch score of 2 (reliable with restrictions) has been assigned to the key value obtained for explosiveness given that the endpoint conclusion was derived as part of an expert assessment of a weight of evidence. Relevant regulation and published documentation were followed as part of a screening procedure.

Justification for classification or non-classification