(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

Guidance on Safe Use

First-aid measures

Eye contact IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists, get medical advice/attention.

Skin contact Take off contaminated clothing and shoes immediately. Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists, call a physician.

Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell

Ingestion Obtain medical attention. Do NOT induce vomiting. Never give anything by mouth to an unconscious person

Medical Surveillance Employees who are pregnant, are breast-feeding, or who are concerned with other reproductive issues should be encouraged to consult with the occupational health physician

monitoring worker's health.

Fire-fighting measures

Flammable Properties Not available

Extinguishing Media Suitable extinguishing media: Dry chemical, Water spray, Foam

Unsuitable extinguishing media: Do NOT use water jet.

Protection of Firefighters

Specific hazards: Refer to HAZARDS IDENTIFICATION section for a description of hazards for this material.

Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained breathing apparatus.

Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx), sulphur compounds

Other information Decontaminate protective clothing and equipment before reuse. Avoid generating dust; fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.

Accidental release measures

Personal precautions Refer to protective measures listed in sections 7 and 8. Use personal protective equipment.

Examples include tightly fitting safety goggles, lab coat and impervious gloves. Wear respiratory protection. Depending on the nature of the spill (quantity and extent of spill) additional protective clothing and equipment such as a self-contained breathing apparatus

may be needed.

Environmental precautions

Prevent release to drains and waterways. Prevent release to the environment.

Containment Methods Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable material.

Cleanup Methods Contain and collect spillage and place in container for disposal according to local regulations (see Section 13). Use a HEPA vacuum or moisten materials to minimize dust generation during pick-up. Clean area with detergent and water after spill pick-up, if appropriate. Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar

materials.

Other information Dust deposits should not be allowed to accumulate on surfaces, as these may form an explosive mixture if they are released into the atmosphere in sufficient concentration.

Avoid dispersal of dust in the air (i.e., clearing dust surfaces with compressed air). Nonsparking tools should be used.

Handling and storage

Handling Precautions Avoid exposure - obtain special instructions before use. Avoid formation of dust and aerosols. Keep away from heat and sources of ignition. Prevent release to drains and waterways. Minimize dust generation and accumulation. Routine housekeeping should be instituted to ensure that dusts do not accumulate on surfaces. Dry powders can build static electricity charges when subjected to the friction of transfer and mixing operations.

Provide adequate precautions, such as electrical grounding and bonding, or inert atmospheres.

Container Requirements

Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.

Storage Conditions Store in well-ventilated place. Keep container tightly closed. Store at room temperature.

Protect against light. Keep away from heat, sparks and flames. Store locked up

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

Not listed

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

Not listed

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

Not listed

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

Not listed

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Recommended Industrial Hygiene

Monitoring Methods A specific exposure sampling method is not available. Contact the Bristol-Myers Squibb AIHA accredited Industrial Hygiene Laboratory at (USA) 732-227-6338.

General - The health hazard risk of handling this material is dependent on many factors, including physical form, % API in material being handled, duration and frequency of process task, and effectiveness of controls. If it is necessary to handle this compound outside of engineering controls, an exposure risk assessment should be conducted and procedures documented by a qualified EHS professional.

Engineering Controls and Ventilation

Use process enclosures, containment technology, or other engineering controls to keep airborne levels below recommended exposure limit. When handling quantities up to 15 milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air changes per hour) is appropriate. When handling quantities from 15 milligrams to 1 kilogram, work in a standard laboratory using a fume hood, biological safety cabinet(Class II, all types), or approved vented enclosure. Quantities exceeding 1 kilogram should be handled in a designated laboratory. A laminar flow/powder containment booth is recommended for handling >1 kilograms of active substance. For manufacturing and pilot plant operations, use direct coupling and closed transfer systems for all bulk transfers. Use dust tight valves as appropriate. HEPA filtration of local exh ust ventilation (LEV) is required. It is recommended that all dust control equipment such as local exhaust ventilation and material transport systems involved in handling of this product contain explosion relief vents or an explosion suppression system or an oxygen deficient environment. Ensure that dust-handling systems (such as exhaust ducts, dust collectors, vessels, and processing equipment) are designed in an manner to prevent the escape of dust into the work area (i.e., there is no leakage from the equipment). Use only appropriately classified electrical equipment and powered industrial trucks

Respiratory protection

Use and selection of respiratory protection is based upon engineering controls in use and potential for aerosol generation. When engineering controls are not sufficient control exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate (HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters (EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied air respirator (EN 139) operated in a pressure demand or other positive pressure mode when

exposures are 100-1000 times the exposure control guideline.

Eye protection Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety goggles (EN 166) may be required if splash potential exists or if corrosive materials are present. Note: Choice of eye protection may be influenced by the type of respirator which is selected.

Hand protection Impervious nitrile, rubber and latex gloves are recommended (EN 420, EN 374). If material is handled in solution, the solvent should also be considered when selecting protective clothing material. Please note that employees who are allergic to natural rubber latex should use nitrile gloves.

Skin and body protection

Wear a laboratory coat (EN 340) when handling quantities up to 1 kilogram. For quantities over 1 kilogram, wear laboratory coat(EN 340)or coverall of low permeability (EN 1149-1). For manufacturing operations, wear coverall of low permeability (EN 465/1149-1). For manufacturing operations, wear coverall of low permeability (EN 1149-1).

Hygiene Wash hands and face before breaks and immediately after handling the product.

Stability and reactivity

Chemical Stability: Stable under normal conditions.

Conditions to avoid: No informatin available

Materials to avoid: bases

Hazardous decomposition products:

Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx), sulphur compounds

Sensitivity to static discharge/Dust exp. Explosion Severity Factor St 1 (assumed) Material exhibits weak to moderate explosion characteristics if ignited as a dustcloud. Minimum Ignition Energy > 10 - < 25 mJ

Material is very susceptible to igniting as a dust cloud under certain conditions due to low minimum ignition energy.

Disposal considerations

Disposal should be in accordance with applicable regional, national and local laws and regulations. Local regulations may be more stringent than regional or national requirements. This information presented only applies to the material as supplied. Other information Disposal by incineration is recommended.