Registration Dossier
Registration Dossier
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EC number: 814-308-5 | CAS number: 63286-42-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Method equivalent or similar to guideline, non-GLP. Information is sufficient to conclude absence of classifiation and labelling when combined with other available information.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Oxacycloheptadec-7-en-2-one
- EC Number:
- 231-929-1
- EC Name:
- Oxacycloheptadec-7-en-2-one
- Cas Number:
- 7779-50-2
- Molecular formula:
- C16H28O2
- IUPAC Name:
- oxacycloheptadec-7-en-2-one
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg bw
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Not reported
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: No
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: No significant effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- EU criteria not met
- Conclusions:
- Under the conditions of this study, the LD50 (male/female) was determined to be > 5000 mg/kg bw
- Executive summary:
The study was performed according to a method equivalent or similar to OECD TG 401 to assess the acute oral toxicity potential of the test item to the rat. Following administration by oral gavage at a dose level of 5000 mg/kg bodyweight there were no mortalities and no significant clinical signs. Under the conditions of this study, the LD50 (male/female) was determined to be > 5000 mg/kg bw.
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