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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Conducted to sound scientific principles. GLP.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1981
Reference Type:
publication
Title:
Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Author:
OECD SIDS
Year:
2002
Bibliographic source:
SIDS Initial Assessment Report for Siam 14-Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
Procedure set forth in the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Source: Nouplaz 6959 Purity: 98.95%

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Covered contact for 24 hours with abraded skin exposed 10% of the body surface area. Observation for 14 days follwed by gross necropsy.
Duration of exposure:
24 h
Doses:
1970 mg/kg/bw
No. of animals per sex per dose:
No. of animals per sex per dose: 3 per sex
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 970 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no mortality was observed
Mortality:
no mortality was observed
Clinical signs:
No toxic signs
Gross pathology:
Nothing noted.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 was > 1970 mg/kg for male and female rabbits.

Classification as a dermal toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Executive summary:

The LD50 was > 1970 mg/kg for male and female rabbits.

Classification as a dermal toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.