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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Conducted to sound scientific principles.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE
Author:
OECD SIDS
Year:
2002
Bibliographic source:
SIDS initial Assessment Report for Siam 14: TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE
Reference Type:
publication
Title:
Tissue distribution and excretion of tris(2-ethylhexyl)trimellitate in rats
Author:
Martis L et al
Year:
1987
Bibliographic source:
J. Toxicol. Envir. Hlth 20, 357-366

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
intravenous

Results and discussion

Applicant's summary and conclusion

Conclusions:
TOTM given intravenously accumulated in the liver (72%), lungs and spleen in rats within 24 hours. Biliary excretion, the main elimination route, was slow indicating a potential for accumulation in these target organs.
Executive summary:

The disposition kinetics of tri-(2-ethylhexyl)trimellitate (TOTM), was studied in rats following intravenous administration of [14C-carbonyl]tri-(2-ethylhexyl)trimellitate using an oil in water emulsion as the vehicle. The distribution half-life, elimination half-life, and clearance values estimated from the plasma concentration of radioactivity data obtained following iv administration of 10.5 mg/kg of TOTM (59.9 muCi/kg), were 46.2 min, 5.34 d, and 40.5 ml/kg h, respectively. Following iv dosage of 15.6 mg/kg of TOTM (28.0 muCi/kg), significant accumulation of radioactivity was found in the liver, lungs, and spleen, with liver accounting for 72% of the administered dosage at 24 h. Excretion of TOTM and its biotransformation products was slow, with 21.3% of the administered radioactivity found in the feces and 2.8% in the urine during the 14-d collection period. Biliary excretion seems to be the major route of elimination of TOTM.