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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Description of key information

Short term and long term toxicity in earthworm - read-across data ( short-term study and  long-term study)
Read-across findings indicate that the submission substance is not expected to cause short-term or long-term toxicity to earthworms.

Key value for chemical safety assessment

Additional information

No earthworm toxicity data are available for the submission substance. CAS No. 70225-05-7, or related trimellitate esters. However, earthworm toxicity data have been reported for the dinonyl phthalate (DINP) (CAS No. 68515-48-0) and di-isodecyl phthalate (DIDP)(CAS No. 68515-49-1), which can provide some useful read-across assessment for the trimellitates. 

From a structure activity relationship perspective, the long-chain alkyl phthalates and the corresponding long-chain trimellitates are chemically similar or related in that they are benzene dicarboxylic or tricarboxylic acid ester analogs of each other. The phthalate substructure (i.e., 1,2-benzenedicarboxylate alkyl ester) is present within the trimellitate structure (i.e., 1,2,4-benzenetricarboxylate alkyl ester) structure. From a toxicological perspective, one would expect trimellitates to be relatively less toxic than the corresponding phthalate analogs owing to its lower water insolubililty and bioavailability. Hence, in the absence of trimellitate surrogate data, available data for the corresponding phthalate esters of similar chain-length, like DINP or DIDP, may be considered as an alternative to help in estimating the potential terrestrial toxicity of the submission substance (CAS No. 70225-05-7) (which is a trimellitate with two C10 and one C13 group).  

Read-across results from a 14-day earthworm study (OECD 207) showed that di-isodecyl phthalate (DIDP) was not acutely toxic and caused no mortality or adverse effects in earthworms exposed to soil concentrations as high as 7664 to 8435 mg/kg dw.

In addition, results from a 56-day earthworm reproduction study show that DINP did not cause any reproductive toxicity at high concentrations as determined in an artificial soil. The 56-day NOEC was 982 mg/kg (d.w.) in artificial soil.   

 

Based on the read-across acute and chronic earthworm toxicity data, the submission substance, CAS No. 70225-05-7, would be expected to cause short-term or long-term toxicity to earthworms.