2-bromo-5-hydroxy-4-methoxybenzaldehyde

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1997-11-27 to 1998-02-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

GLP study performed according to OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) and Standardisation Committee for the building and construction industry of DIN Deutsches Instituet fuer Normung e. V., Determination of soil sampies, DIN 18123 “Bestimmung der Korngrossenverteilung”, adopted April 1983 without deviations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Deviations:

no

Remarks:

The testing facility indicated that the protocol was followed without deviations

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: Standardisation Committee for the building and construction industry of DIN Deutsches Instituet fuer Normung e. V., Determination of soil sampies, DIN 18123 “Bestimmung der Korngrossenverteilung”, adopted April 1983

Deviations:

no

Remarks:

The testing facility indicated that the protocol was followed without deviations

Principles of method if other than guideline:

not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Certificate issued by the Ministerium fuer Umwelt, Energie und Verkehr des Saarlandes

Type of method:

sieving

Type of distribution:

mass based distribution

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

426-540-0

EC Name:

-

Cas Number:

2973-59-3

Molecular formula:

C8 H7 Br O3

IUPAC Name:

2-bromo-5-hydroxy-4-methoxybenzaldehyde

Test material form:

solid

Specific details on test material used for the study:

- Batch: 00265786
- Purity: 91.3% (HPLC purity)
- Expiration date: July 1, 1998 (retest date)
- Storage: at room temperature at about 20°C

Results and discussion

Particle size

Percentile:

D50

Mean:

107 µm

Remarks on result:

other: mass mean diameter

Particle size distribution at different passages

Particle size distribution at different passages 1

No.:

#1

Size:

> 200 µm

Distribution:

14.2 %

Particle size distribution at different passages 2

No.:

#2

Size:

>= 160 - < 200 µm

Distribution:

3.32 %

Particle size distribution at different passages 3

No.:

#3

Size:

>= 125 - < 160 µm

Distribution:

7.91 %

Particle size distribution at different passages 4

No.:

#4

Size:

>= 90 - < 125 µm

Distribution:

51.4 %

Particle size distribution at different passages 5

No.:

#5

Size:

>= 63 - < 90 µm

Distribution:

5.11 %

Particle size distribution at different passages 6

No.:

#6

Size:

>= 40 - 63 µm

Distribution:

11.7 %

Particle size distribution at different passages 7

No.:

#7

Size:

>= 32 - < 40 µm

Distribution:

3.75 %

Particle size distribution at different passages 8

No.:

#8

Size:

>= 15 - < 32 µm

Distribution:

3.55 %

Particle size distribution at different passages 9

No.:

#9

Size:

>= 8 - < 15 µm

Distribution:

0.63 %

Particle size distribution at different passages 10

No.:

#10

Size:

< 8 µm

Distribution:

0 %

Any other information on results incl. tables

The test substance was judged visually to be a light brown powder. The fine powder contained agglomerates, which could be destroyed with a mortar and pestle. The test substance was found to consist of rod-shaped transparent particles with a plane surface in the preliminary test using a microscope.

The sieving was performed in triplicate experiments. The results obtained in the first and second experiment showed a relevant difference; therefore a further sieving test was performed. The mean mass fraction (weight%) results obtained in the third and second experiment showed no relevant difference. Therefore the study is considered to be valid and no further sieving tests had to be performed. The total percent mass recovered in experiments I, II and III were 98.9, 102 and 101%, respectively. The results of the first experiment were not used for the further evaluation of results, but confirm the results found for the particle size lower than 10 um in the second and third experiment.

From the particle size distributions for experiments I and II (see attached Figure 1), a mass median diameter (MMD) of ca. 107 µm was found.

Applicant's summary and conclusion

Conclusions:

In conclusion, it could be stated that < 0.25 wt % of the particles showed a particle size smaller than 10 µm. About 50 wt % of the test substance were determined by sieve analysis to be smaller than about 107 µm (median mass diameter).