Registration Dossier
Registration Dossier
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EC number: 249-200-1 | CAS number: 28754-28-1
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1989
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- 24 h test
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-(5-chlorobenzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
- EC Number:
- 252-722-2
- EC Name:
- 3-(5-chlorobenzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
- Cas Number:
- 35773-43-4
- Molecular formula:
- C20H17ClN2O3
- IUPAC Name:
- 3-(5-chloro-1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Stock solution (12 g/L) prepared, stirred for 3 h and diluted with test medium for test concentrations
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
Test conditions
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5 623 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: EC50 calculated as geometric mean value of EC0 and EC100
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 3 142 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 24-h EC50 was calculated as geometric mean value of EC0 and EC100 at 5632 mg/L (nominal). The effect values are far above the water solubility limit.
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