Registration Dossier
Registration Dossier
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EC number: 203-385-5 | CAS number: 106-32-1
Endpoint summary
Administrative data
Description of key information
There are two a human maximisation studies available from 1975. In a pre-test for these two studies, irritation was also tested.
Irritation: no reactions were observed.
Maximisation: in the first study 2 reactions were observed. In the second study there were no reactions reported.
Additional information
Irritation:
In two studies, irritation was evaluated prior to human maximisation studies (same as below studies), and 48-hour occluded patch test
were conducted on the forearms or backs of 25 and 5 subjects, respectively, with ethyl octanoate at 2% in petrolatum. No reactions were
observed.
Maximisation:
Two human maximisation studies were conducted on 25 subjects with ethyl octanoate at 2% in petrolatum. Occluded applications were made for five alternate-day 48-hour periods to the forearms or backs, and the sites were pretreated for 24 hours with 2.5 - 5% aqueous sodium lauryl sulfate (SLS) under occlusion. The occluded challenge patches were applied for 48 hours after a rest period of 10 - 14 days. The reactions were read at the patch removal and 24 hours after the patch removal. In the first study two reactions were observed, in the second study there were no reactions reported.
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