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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental starting date: 06 April 2018 Experimental completion date: 14 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC estimation method
Specific details on test material used for the study:
Identification: ESA (1,3,2-Dioxathiolane, 2,2-dioxide)
Appearance/Physical state: White solid
Batch Number: ESA-170926-160
Purity: 100.0%
Expiry date: 25 June 2018
Storage conditions: Approximately -20 °C, in the dark
Test temperature:
25 °C
Details on study design: HPLC method:
The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.

Performance of the Test

Preparation of sample solution
Test item (0.1002 g) was diluted to 100 mL with methanol: purified water (55:45 v/v), to give a concentration of 1.00 g/L.

Preparation of dead time solution
The dead time was determined by measuring the retention time of formamide (purity* 99.6%) of a 817 mg/L solution in methanol: purified water (55:45 v/v).

Preparation of reference standard solutions
Solutions of reference standards were prepared in methanol.

Determination of retention time
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:

HPLC System: Agilent Technologies 1200, incorporating workstation and autosampler
Detector type: variable wavelength (VW)
Column: Agilent Eclipse XDB-CN 5µ m (150 x 4.6 mm id)
Column temperature: 25 °C
Mobile phase: Methanol: purified water (55:45 v/v)
pH of mobile phase: 6.0
Flow-rate: 1.0 mL/min
Injection volume: 10 µ L
VW detector wavelength: 210 nm
Type:
log Koc
Value:
< 1.25 dimensionless
pH:
6
Temp.:
25 °C
Type:
Koc
Value:
< 18 dimensionless
pH:
6
Temp.:
25 °C
Details on results (HPLC method):
The test item has no mode of dissociation. Therefore, the test was performed at approximately neutral pH with the test item in a non-ionized form.

Calibration

The retention times of the dead time and the retention times, capacity factors (k') and log10Koc values for the reference standards are shown in the two following tables:

 

 

Dead Time

Retention Time (min)

Mean Retention Time (min)

Injection 1

Injection 2

Formamide

1.674

1.674

1.674


 

 

Standard

Retention Time (min)

Mean Retention Time (min)

Capacity Factor (k')

 

Log10k'

 

Log10Koc

Injection 1

Injection 2

Acetanilide

2.203

2.203

2.203

0.316

-0.500

1.25

Phenol

2.263

2.263

2.263

0.352

-0.453

1.32

Atrazine

2.647

2.647

2.647

0.581

-0.236

1.81

Triadimenol

3.624

3.622

3.623

1.16

0.066

2.40

Linuron

4.362

4.362

4.362

1.61

0.206

2.59

Naphthalene

4.003

4.003

4.003

1.39

0.143

2.75

Endosulfan-diol

5.597

5.599

5.598

2.34

0.370

3.02

Fenthion

7.584

7.586

7.585

3.53

0.548

3.31

a-Endosulfan

9.153

9.156

9.155

4.47

0.650

4.09

Diclofop-methyl

8.916

8.918

8.917

4.33

0.636

4.20

 

 

Adsorption Coefficient

The retention times, capacity factor and log10Koc value determined for the sample are shownin the following table:

 

Injection

Retention Time (min)

Capacity Factor (k')

Log10k'

Log10Koc

1

< 2.203

< 0.316

< -0.500

< 1.25

2

< 2.203

< 0.316

< -0.500

< 1.25

 

Mean log10Koc: Less than 1.25

Adsorption coefficient: Less than18

Validity criteria fulfilled:
yes
Conclusions:
The adsorption coefficient of the test item has been determined to be less than 18, log10 Koc less than 1.25. The result classified the test item as having very high mobility.
Executive summary:

The adsorption coefficient of ESA (1,3,2-Dioxathiolane, 2,2-dioxide) has been determined tobe less than 18, log10Koc, less than 1.25, using the HPLC screening method, designed to becompatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The result classified the test item as having very high mobility.

Description of key information

The adsorption coefficient of ESA (1,3,2-Dioxathiolane, 2,2-dioxide) has been determined to be less than 18, log10Koc less than 1.25, using the HPLC screening method, designed to becompatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The result classified the test item as having very high mobility.

Key value for chemical safety assessment

Koc at 20 °C:
18

Additional information