Registration Dossier
Registration Dossier
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EC number: 200-782-5 | CAS number: 72-48-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Skin irritation
In a recent in vitro skin irritation study the test item showed a mean relative tissue viability of 88.1%.
The test item is considered irritant to the skin if the mean relative tissue viability of three individual tissues is reduced ≤ 50% of the negative control. Thus, based on the available data on skin irritation, the test item does not meet the criteria for classification according to Regulation (EC) 1272/2008 (CLP).
Eye irritation
In a recent in vitro eye irritation study (BCOP) the 3 corneas treated with the test item showed intense opacity and a rose discolouration of the tissue. The following mean in vitro irritation score was calculated: 95.93
It cannot be excluded that the high opacity score may be related to the rose discoloration of the tissue but due to the observed intense opacity of the treated corneas and the high rate of the score, an eye irritancy potential of the test item is assumed.
Based on the available data on eye irritation, the test item meets the criteria for classification according to Regulation (EC) 1272/2008 (CLP) as Eye damage, category 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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