Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 August 2017 - 20 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): yttrium trifluoride
- Physical state: solid
- Appearance: white powder
- Further information on test material confidential.

Results and discussion

Water solubilityopen allclose all
Key result
Water solubility:
< 0.03 mg/L
Conc. based on:
element (dissolved fraction)
Remarks:
Y
Temp.:
20 °C
pH:
6
Remarks on result:
other: Expressed as yttrium content in water; mean at flow rates of 12.5 mL/h and 25 mL/h.
Key result
Water solubility:
< 0.1 mg/L
Conc. based on:
test mat. (dissolved fraction)
Remarks:
Result calculated based on dissolved Y measurements.
Temp.:
20 °C
pH:
6
Remarks on result:
other: Mean at flow rates of 12.5 mL/h and 25 mL/h.
Details on results:
Results were validated by:
- Linearity validation: The analysis showed a good linearity of the method (r > 0.99).
- Accuracy validation: Results in dilution mixture showed a good accuracy which indicates acceptable data (recoveries ranged between 70 and 110%).
- Repeatability validation: The results indicated a good precision of the data (RSD < 20%).
- Specificity: The intensity (CPS) of blank samples measured was negligible.
- Limit of quantification: 0.015 mg Y/L
- Limit of detection: 0.005 mg Y/L

Any other information on results incl. tables

Results of the preliminary test with milliQ water and at pH 6 were:

Amount of test item weighed (g) 0.1 0.1 0.1 0.1 0.1 0.1  0.01
Volume of water added (mL) 0.1 0.5 1 2 10 100 1000
Solubility (yes/no) No No  No  No No  No No (after > 96 h of agitation of the test solution)

Results of the main test:

 

Solubility expressed as

yttrium content in water

(mg/L)

Solubility of yttrium fluoride in water

(mg/L)

Mean pH measured

Temperature

(°C)

Test 1

(flow 25 mL/h)

 < 0.02

 < 0.03

 6

 20

Test 2

(flow 25 mL/h)

 0.03  0.05  6  20
Mean (Test 1 and Test 2)  < 0.03  < 0.05  6  20

Test 3

(flow 12.5 mL/h)

 0.03

 < 0.05

 6

 20

Mean (12.5 mL/h and 25 mL/h)

 < 0.03  < 0.05 rounded at < 0.1  6  20

Applicant's summary and conclusion

Conclusions:
The water solubility of yttrium trifluoride was determined to be < 0.1 mg/L at pH 6 and at 20°C. This result was calculated from the measured yttrium content in water which was < 0.03 mg/L (column elution method).