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EC number: 248-655-3 | CAS number: 27776-21-2
The toxicity of Azo Initiator VA044 to the unicellular freshwater green alga Pseudokirchneriella subcapitata was determined according to the principles of OECD 201 and Council Regulation (EC) No. 440/2008/ method C.3 from 2014 -11 -03 to 2014 -11 -06 at Dr. U.Noack-Laboratorien in 31157 Sarstedt, Germany. The aim of the study was to assess the effects on the growth rate over a period of 72 hours.
The test item Azo Initiator VA044 is a white powder and has a water solubility of 347 g/L at 25 °C. The stock solution of 80.0 mg/L was freshly prepared with dilution water. Further test concentrations were prepared by diluting the stock solution with dilution water. The tested solutions were slightly yellow with precipitation.
The study was conducted under static conditions with an intial cell density of 7085 cells/mL and reduced light intensity dur to the light sensitivity of the test item. Based on a preliminary range finding test, five concentratin levels were tested in a geometrical series with a dilution factor of 2.2 (nominal): 1.16 - 2.56 - 5.64 - 12.4 - 27.3 - 60 mg/L, corresponding a geometric mean measured test item concentrations of 0.762 - 1.60 - 3.66 - 8.44 - 18.3 - 38.8 mg/L. Three replicates were tested for each test item concentration and six replicates for the control. The environmental conditions were within the acceptable limits.
All test concentrations of Azo Initiator VA044 and the control were analytically verified by LC-MS/MS at the start and the and of the exposure. The measured concentrations of VA044 at the start of the exposure were in the range of 94 - 109 % of the nominal test item concentrations and 39 - 45 % at the end of the exposure.
All effect values are based on the geometric mean measured concentrations of the test item Azo Initiator VA044. The growth inhibition results of the test item are summarized below:
ErC10 < 0.762 mg/L
ErC20 2.13 (1.58 -2.77) mg/L
ErC50 13.5 (11.4 -16.1) mg/L
Based on the results of the available study exposing Pseudokirchneriella subcapitata for 72 hours an ErC50 -value of 13.5 mg/L and an ErC10 -value < 0.762 mg/L were determined. The short-term value is used as point of departure for the PNEC calculations.
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