Registration Dossier
Registration Dossier
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EC number: 285-413-6 | CAS number: 85098-62-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 September 2017 to 9 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.24 (Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 1.6
- Temp.:
- 25 °C
- pH:
- 5.4
- Details on results:
- The three calibration series and three test material series were measured alternately. The partition coefficient Pow was determined based on a calibration curve using 6 reference substances.
The capacity factors k were calculated from the dead time and retention times of the reference substances. The log k data of the reference substances were plotted against their log Pow values. The resulting calibration curve is attached to this study summary.
The capacity factor k and log Pow for the test material could not be determined by using this method, because the retention time of the test material was found to be less than the retention time of thiourea (dead time). - Conclusions:
- The estimated log Pow of test material on the chromatograms is <1.6.
- Executive summary:
The partition coefficient of the test material was investigated in a study which was conducted under GLP conditions and in accordance with the standardised guidelines EU Method A.24 and OECD 117, using the HPLC Method.
Under the conditions of the study it was concluded the log Pow for the test material could not be determined because the retention time of the test material was found to be less than the retention time of thiourea (dead time).
The estimated log Pow of test material on the chromatograms is <1.6.
Reference
Description of key information
The estimated log Pow of test material on the chromatograms is <1.6.
Key value for chemical safety assessment
Additional information
The partition coefficient of the test material was investigated in a study which was conducted under GLP conditions and in accordance with the standardised guidelines EU Method A.24 and OECD 117, using the HPLC Method.
Under the conditions of the study it was concluded the log Pow for the test material could not be determined because the retention time of the test material was found to be less than the retention time of thiourea (dead time).
The estimated log Pow of test material on the chromatograms is <1.6.
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