Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 297-025-4
CAS number: 93281-13-1
The number of PCEs (Polychromatic
Erythrocytes) with micronuclei and the ratio of PCE to NCE (
Normochromatic Erythrocyte) are given for each test group in the table
Summary of results.
The substance was assessed in the
micronucleus assay for its potential to induce micronuclei in
polychromatic erythrocytes (PCE) in the bone marrow of the mouse,
according to the OECD Guideline 474 and EU Method B12. Six male and six
female mouses were treated orally with a single dose of 5000 mg/kg b.w.
This was the maximum attainable dose as estimated by the pre-experiment.
Concurrent positive (use of cyclophosphamide) and negative (use of
vehicle-distilled water) control groups run. After 24 h, 48 h and 72
hours the bone marrow cells of ten animals were collected for
micronuclei analysis. 1000 polychromatic erythrocytes (PCE) per animal
were scored for micronuclei.
In comparison with the corresponding
negative controls there was no substantial enhancement in the frequency
of the detected micronuclei at any preparation interval after
application of the test article. The mean values of micronuclei observed
after treatment with the substance were in the same range as compared to
the negative control groups.
The test article did not induce
micronuclei in the bone marrow cells of the mouse, under the test
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again