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EC number: 297-025-4
CAS number: 93281-13-1
The following table presents the
revertants/plate mean for the three experiments for each strain.
The substance was assessed for its
potential to induce gene mutations according to the plate incorporation
test using Salmonella typhimurium strains TA1535, TA1537, TA1538,
TA98 and TA100. The assay was performed in two independent experiments,
using identical procedures, both with and without rat liver microsomal
activation. According to the results of these experiments, a third
experiment (III) was performed only with TA1535 and TA1537 with and
without metabolic activation. Five concentrations (10.0, 100.0, 333.3,
1000.0 and 5000.0 μg/plate) including the control were inoculated with
each of the strains for 72 hours at 37 °C. Each concentration was tested
Toxic effects occurred in strain TA1535 at
100.0 μg/plate (exp. I) and in strain TA1537 at 1000.0 μg/plate (exp.
Ill) both without S9 mix. Also in strain TA 98 at 5000.0 μg/plate with
metabolic activation in both experiments. The plates incubated with the
test article showed normal background growth up to 5000.0 ug/plate with
and without S9 mix in all strains used. In strain TA1537 (with S9 mix) a
dose-dependent increase in the number of revertants was observed in the
concentration range of 333.3 up to 5000.0 ug/plate. This increase was
less significant in exp. II. In the experiment III no relevant increase
in the number of revertants was observed. Based on these results a
mutagenic potential of the test article in strain TA1537 cannot be
excluded, but this the effect was not reproduced in all three
experiments. In strain TA1538 (with S9 mix) a dose-dependent increase
was obtained up to 333.3 μg/plate (exp. I) and up to 1000.0 μg/plate
(exp. ΙI). No indication of mutagenic response occured in strains
TA1535, TA 98, and TA 100 as compared to the solvent control nor a
concentration-dependent enhancement of the revertant number exists, with
and without metabolic activation. The substance induced point mutations
by frameshifts in the genome of the strain TA1538 and there is an
indication of a possible mutagenic response in strain TA1537.
Under the tested conditions, the test
article induced point mutations by frameshifts in the genome of strain
TA1538. There was also an indication of a possible mutagenic response in
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