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EC number: 297-025-4
CAS number: 93281-13-1
The eye irritation scores for each animal
are presented in the table below.
- : non quantifiable due to the colouring
from test substance.
The substance was assessed for eye
irritation potential to rabbits, according to the OECD guideline 405.
The right eye of three male rabbits was treated with the substance (non
diluted) and after 24 hours the eyes were washed.
In the course of the first 24 hours after
administration, the substance induced edematic lesions, ranging from
some swelling above normal of the lids (grade 1) to more than halfclosed
lids (grade 4). Also observed were injected vessels in the bulbar
conjunctivae of all animals and discharge ranging from mild to
moistening of the lids and surrounding hair, affecting a considerable
area around the eye. All the animals showed opacity of the cornea (grade
1) ranging from an affected area of one quarter (grade 1) to near
totality of the cornea (grade 4). Due to the colouring produced by the
test substance in the palpebral conjunctivae and iris of some of the
animals, diffused crimson vessels (grade 3) were observed in only one
animal. 2, 3 and 4 days following administration, observed ocular
injuries had begun to subside.
In the reading carried out 7 days
post-administration, one animal showed vessels clearly more injected
than normal (grade 1) in the palpebral conjunctivae. Also, another
animal showed nearly half closed, swollen lids (grade 3) and opacity of
the cornea (grade 1) which occupied less than one quarter of the total
area (grade 1).
The substance is considered to be an eye
irritant to rabbits.
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