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EC number: 297-025-4
CAS number: 93281-13-1
The skin irritation scores for each animal
are presented below.
The mean scores for skin irritation as a
mean of 24, 48 and 72 hours are presented below.
The irritancy potential of the test
material to the skin of New Zeland white rabbit was assessed, according
to the OECD Guideline 404. The intact skin of the rabbits was exposed
for 4 hours to the substance, in a semi-occlusive dressing. Animals were
examined for signs of erythema and edema and the responses were scored
at 1 hour following the patch and substance removal/washing, and then
24, 48 and 72 hours later.
No acute clinical symptoms were observed
and no mortality occurred. A black coloration on the back was observed
in all animals from 1 to 72 hours, but no signs of irritations were
observed. Test item showed a primary irritation score of 0.00 when
applied to intact rabbit skin. Local signs (mean values from 1 hour to
72 hours) consisted of grade 0.00 erythema and grade 0.00 edema.
The substance is not a skin irritant.
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