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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
log Pow
Partition coefficient:
< -4
Temp.:
25 °C
pH:
6
Details on results:
The following concentrations were obtained after equilibrium:
c (octanol) < 3.10 ^-8 mol/l. No test compound could be detected in the octanol phase, by backextraction (10:1 octanol:H2O) into water and spectrophotometric measurement in water.
c (water): 2.96.10 ^-4 mol/l

The value of LogPow obtained shows that the expected Pow lies outside the range of flask shaking method and should be estimated by the calculation method.
Conclusions:
Log Pow < -4 at 25 °C and pH 6.0
Executive summary:

The partition coefficient was first evaluated by using the shake flask method, according to the OECD Guideline 107.

The value of LogPow obtained shows that the expected Pow lies outside the range of flask shaking method and it was suggested that it should be estimated by the calculation method.

Conclusion

Log Pow < -4 at 25 °C and pH 6.0

Description of key information

lower than -4 at 25 °C and pH 6.0

Key value for chemical safety assessment

Log Kow (Log Pow):
-4
at the temperature of:
25 °C

Additional information

OECD Guideline 107 - shake-flask method