Registration Dossier
Registration Dossier
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EC number: 220-378-2 | CAS number: 2744-49-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Fluorescent Brightener 121
- IUPAC Name:
- Fluorescent Brightener 121
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- - Concentration vehicle: 20 %
- Doses:
- 2000 mg/kg bw
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No lethality at 2000 mg/kg bw.
- Clinical signs:
- No symptoms at 2000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified, according to the CLP Regulation (EC) No 1272/2008
- Conclusions:
- LD50 (male and female) > 2000 mg/kg bw
- Executive summary:
Male and female Wistar rats were treated with test item, by oral administration, at a dosage of 2000 mg/kg body weight. The test was conducted according to tyhe OECD guideline 401. The test item was diluted in vehicle (sesame oil 20 %). No lethality and symptoms were recorded at 2000 mg/kg bw.
Conclusion
LD50 (male and female) > 2000 mg/kg bw
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