Registration Dossier
Registration Dossier
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EC number: 807-380-4 | CAS number: 377734-55-9
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Reported 19Jan2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- no
- Other quality assurance:
- other: ISO9001
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 7-hydroxy-N,N,N-trimethylnaphthalen-2-aminium methyl sulfate
- Cas Number:
- 377734-55-9
- Molecular formula:
- C14H19NO5S
- IUPAC Name:
- 7-hydroxy-N,N,N-trimethylnaphthalen-2-aminium methyl sulfate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- NBTRI
RK0400 16-09-01 (Spray Dried)
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.018
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- In a separating funnel 100ml of distilled water was added followed by 100 ml of octan-1-ol, this was
then shaken and left to settle for 10 minutes. 0.4823g of sample was added to the separating funnel,
this was shaken for 1 minute. The solution was then left overnight to allow the 2 phases to separate.
The next day the phases were separated into 2 100 ml volumetric flasks. These solutions were then
measured on the spectrophotometer using the relevant solvent as a blank.
Abs in octan-1-ol 0.544088@ 330 nm
Abs in water 1.49172 @330 nm (20 fold dilution required to get the abs in range)
0.544088 / 29.8344 = 1.8×10-2
Applicant's summary and conclusion
- Conclusions:
- The Pow was experimentally determined to be 0.018 in a lab with a constant temperature of 20°C.
- Executive summary:
The Pow was experimentally determined to be 0.018 in a lab with a constant temperature of 20°C.
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