Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1955
Report date:
1955

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Two rats per dose level were orally treated with different doses of the test substance vinylbenzyl chloride in corn oil.
GLP compliance:
no
Test type:
other: not specified, probably similar to standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
(chloromethyl)vinylbenzene
EC Number:
250-005-9
EC Name:
(chloromethyl)vinylbenzene
Cas Number:
30030-25-2
Molecular formula:
C9H9Cl
IUPAC Name:
1-(chloromethyl)-3-ethenylbenzene; 1-(chloromethyl)-4-ethenylbenzene
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Remarks:
10 %
Doses:
0.126, 0.252, 0.5, 1.0 g/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Statistics:
not reported

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 500 - < 1 000 mg/kg bw
Based on:
test mat.
Mortality:
Mortality occurred in 1 day after exposure to 1000 mg/kg bw (2 of 2 rats).

Any other information on results incl. tables

Animal Preparation Fed Dose (g/kg) No died / No fed Response-Remarks
Rat 10 % in corn oil 0.126 0/2 Slight irritation of the stomage. No other symptoms noted.
0.252 0/2 Moderate irritation of the stomach and slight kidney pathology noted.
0.5 0/2 Slight initial weight loss.
1.0 2/2 Death occured in 1 day.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
This material vinylbenzyl chloride has a moderate acute oral toxicity. After oral uptake of 1 g of test substance per kg body weight (10 % in corn oil) death of the treated rat occured in one day.
Executive summary:

Two rats were treated with different doses of the test substance vinylbenzyl chloride in corn oil. At a concentration of 1 g/kg all test animals died after 1 day. At a dose of 0.5 g/kg only slight initial weight loss occured, at 0.252 g/kg moderate irritation of the stomach and slight kidney pathology was noted and at a dose of 0.126 g/kg slight irritation of the stomach and no other symptoms were noted.