Registration Dossier
Registration Dossier
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EC number: 617-813-7 | CAS number: 861960-34-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- (7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
- EC Number:
- 617-813-7
- Cas Number:
- 861960-34-1
- Molecular formula:
- C13H13NO
- IUPAC Name:
- (7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
Constituent 1
In vivo test system
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- other: Individual clinical observations and mortality data
- Value:
- ca. 0
- Key result
- Parameter:
- other: Body change
- Value:
- >= -0.3 - <= 0.8
- Key result
- Parameter:
- SI
- Value:
- ca. 1.35
- Test group / Remarks:
- 10% V/V
- Key result
- Parameter:
- SI
- Value:
- ca. 1.68
- Test group / Remarks:
- 25% V/V
- Key result
- Parameter:
- SI
- Value:
- ca. 1.16
- Test group / Remarks:
- 50% V/V
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was considered to be non-sensitizer to the skin.
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