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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 November 2017 - 05 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Key result
Water solubility:
1.3 mg/L
Conc. based on:
element (dissolved fraction)
Remarks:
Y
Temp.:
20 °C
pH:
6
Remarks on result:
other: Expressed as yttrium content in water; mean at flow rates 12.5 mL/h and 6.25 mL/h.
Details on results:
The mean solubility in water is 1.3 mg Y/L at pH 6 and 20°C.
This value is calculated as the mean of the solubility measured at a flow rate of 6.25 mL/h and the mean solubility measured at a flow rate of 12.5 mL/h.
The results obtained at a flow rate of 25 mL/h were not used for calculation of the final water solubility value as no stable column elution results were obtained.

Result of test 1: Mean 0.3 mg/L discarded data - not stable (at 25 mL/h, pH 6.0 and 20°C)
Result of test 2: Mean 0.3 mg/L discarded data - not stable (at 25 mL/h, pH 6.0 and 20°C)
Result of test 3: 1.4 mg/L (at 12.5 mL/h, pH 6.0 and 20°C)
Result of test 4: 1.6 mg/L (at 12.5 mL/h, pH 6.0 and 20°C)
Result of test 5: 1.1 mg/L (at 6.25 mL/h, pH 6.0 and 20°C)

Results were validated by:
- Linearity validation: The analysis showed a good linearity of the method (r > 0.99).
- Accuracy validation: Results in dilution mixture showed a good accuracy which indicates acceptable data (recoveries ranged between 70 and 110%).
- Repeatability validation: The results indicated a good precision of the data (RSD < 20%).
- Specificity: The intensity (CPS) of blank samples measured was negligible.
- Limit of quantification: 0.25 mg Y/L
- Limit of detection: 0.05 mg Y/L

Results of the preliminary test with milliQ water and at pH 6 were:

Amount of test item weighed (g)

  0.1               

 0.01  

 Volume of water added (mL)

0.1  0.5  1 2  10 100  1000

 Solubility (yes/no)

 No No  No  No  No  No  No (after > 96 h of agitation of the test solution)

Results of the main test

 

Flow rate

Solubility of yttrium content in water (mg/L)

Mean pH measured

Temperature (°C)

 Test 3

12.5 mL/h

1.4

6

20

 Test 4

12.5 mL/h

1.6 6 20
 Mean (Test 3 and Test 4)

12.5 mL/h

1.5 6 20

 Test 5

6.25 mL/h

1.1

6

20

 Mean

12.5 mL/h and 6.25 mL/h

1.3 6 20

Results of Test 1 and Test 2 (at a flow rate of 25 mL/h) were discarded due to instable column elution results.

Conclusions:
The water solubility of the test item at pH 6 and 20°C was determined to be 1.3 mg/L (expressed as yttrium content in water).

Description of key information

Based on a reliable guideline study (Jean-Baptiste, 2018, Klimisch score 1) it can be concluded that the water solubility of the test item at 20°C and pH 6 is 1.3 mg/L (expressed as yttrium content in water). Results of this study can be considered reliable without restriction.  

Key value for chemical safety assessment

Water solubility:
1.3 mg/L
at the temperature of:
20 °C

Additional information