Registration Dossier
Registration Dossier
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EC number: 204-588-1 | CAS number: 122-98-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal standard: Two Vienna White rabbits were subjected to the test substance for 24 hours and observed for 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-anilinoethanol
- EC Number:
- 204-588-1
- EC Name:
- 2-anilinoethanol
- Cas Number:
- 122-98-5
- Molecular formula:
- C8H11NO
- IUPAC Name:
- 2-(phenylamino)ethan-1-ol
- Details on test material:
- - Name of the test substance used in the study report: Mono-oxaethylanilin
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: saline treated eye of the same animal
- Amount / concentration applied:
- 1 x 50 mm3 = 0.05 mL
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritant / corrosive response data:
- - 1 hour after exposure: slight redness, marked edema, and marked opacity was observed
- 24 hours after exposure: marked redness, marked edema, and white nictitating membrane was observed
- 8 days after exposure: slight redness, slight edema, marked opacity and slight scarring was observed
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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