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EC number: 244-942-2 | CAS number: 22374-89-6
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound 1-methyl-3-phenylpropylamine (CAS no. 22374 -89 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1-methyl-3-phenylpropylamine is expected to be not readily biodegradable.
Biodegradation in water and sediment
Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound 1-methyl-3-phenylpropylamine (CAS No. 22374 -89 -6). If released in to the environment, 24.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 1-methyl-3-phenylpropylamine in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 1-methyl-3-phenylpropylamine in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.15%), indicates that 1-methyl-3-phenylpropylamine is not persistent in sediment.
Biodegradation in soil
The half-life period of 1-methyl-3-phenylpropylamine (CAS No. 22374 -89 -6) in soil was estimated using Level III Fugacity Model by EPI Suite estimation database. If released into the environment, 74% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1-methyl-3-phenylpropylamine in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 1-methyl-3-phenylpropylamine, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Predicted data for the target compound 1-methyl-3-phenylpropylamine (CAS No. 22374-89-6) and various supporting weight of evidence studies for its functionally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction using the Estimation Programs Interface Suite (2018), the biodegradation potential of the test compound1-methyl-3-phenylpropylamine(CAS No. 22374-89-6) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical1-methyl-3-phenylpropylamineis expected to be not readily biodegradable.
For the test chemical, 28 -days Closed Bottle test following the OECD guideline 301 D to determine the ready biodegradability of the test item (2017). The test system included control, test item and reference item. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test item and reference item. The BOD28 value of test substance was observed to be 0.45 mgO2/mg. ThOD was calculated as 1.87 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to Closed Bottle test was determined to be 24.06%. Based on the results, the test item, under the test conditions was considered to be not readily biodegradable at 20 ± 1°C over a period of 28 days.
In a supporting weight of evidence study from authoritative database (2017) for the test chemical,biodegradation experiment in refinery wastewater was conducted for 23 days for evaluating the percentage biodegradability of test substance. The study was performed under aerobic conditions using natural microbial flora as a test inoculum. The percentage degradation of test substance was determined to be 0% after a period of 23 days. Thus, based on percentage degradation, test item is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical 1-methyl-3-phenylpropylamine (from modelling database, 2018), it can be concluded that the test substance 1 -methyl-3 -phenylpropylamine can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound 1-methyl-3-phenylpropylamine (CAS No. 22374 -89 -6). If released in to the environment, 24.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 1-methyl-3-phenylpropylamine in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 1-methyl-3-phenylpropylamine in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.15%), indicates that 1-methyl-3-phenylpropylamine is not persistent in sediment.
Biodegradation in soil
The half-life period of 1-methyl-3-phenylpropylamine (CAS No. 22374 -89 -6) in soil was estimated using Level III Fugacity Model by EPI Suite estimation database. If released into the environment, 74% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1-methyl-3-phenylpropylamine in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 1-methyl-3-phenylpropylamine, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance 1-methyl-3-phenylpropylamine can be considered to be not readily biodegradable in nature.
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