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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
yes
Remarks:
Due to the nature of the sample, boiling point was determined by thermogravimetric analysis (TGA) rather than DSC
Principles of method if other than guideline:
Due to the nature of the sample, boiling point was determined by thermogravimetric analysis (TGA), which is a deviation from OECD Guidelines for The Testing of Chemicals, 103, July 27 1995. The sample was dried under a nitrogen purge to remove water from the sample.
An attempt was made to determine the boiling point of the sample by the Siwoloboff method in a heated metal block using photocell detection consistent with OECD Guidelines for The Testing of Chemicals, 103, July 27 1995. This test method is unsuitable for viscous and solid samples. As a result, a deviation from the OECD 103 guideline was necessary and the boiling point test was obtained by performing thermogravimetric analysis (TGA) on the dried sample.
Using thermogravimetric analysis, the sample is placed in a DSC hermetic pan with a laser drilled pinhole in the lid. When the sample starts to boil, the vapor pressure in the pan increases causing a weight loss through the pinhole in the lid. The onset of the derivative of this weight loss is taken to be the boiling point of the sample.
The boiling point was measured using a TA Instruments 2950 TGA and hermetic pin-hole DSC pans. Approximately 4 mg samples were analyzed. The sample was heated from room temperature to 500°C at 5°C/min. Two replicate trials were performed.
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
other: Thermogravimetric analysis (TGA)
Specific details on test material used for the study:
Chemical Name Cetyl Betaine
Physical State liquid - The sample was dried under a nitrogen purge to remove water from the sample.
CAS # 693-33-4
EU # 211-748-4
Sample ID 53841K16
Manufacturer DeForest
Received on November 22, 2016
Tested on February 6, 2017Sample:
Key result
Boiling pt.:
>= 189 - <= 201 °C
Decomposition:
no
Remarks on result:
other: Atm Pressure not reported

The largest boiling component has an average boiling point of 195°C and is not completely resolved from several higher boiling components. This is reported as the boiling point. Variability of the replicates may be caused by inhomogeneity in the dried sample.

Conclusions:
The TGA results indicate that the sample has several components boiling at different temperatures. The lowest boiling component is most likely a trace amount of remaining water left after drying. The largest boiling component has an average boiling point of 195°C and is not completely resolved from several higher boiling components.

Description of key information

The TGA results indicate that the sample has several components boiling at different temperatures. The lowest boiling component is most likely a trace amount of remaining water left after drying. The largest boiling component has an average boiling point of 195°C and is not completely resolved from several higher boiling components.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
195 °C

Additional information

Due to the nature of the sample, boiling point was determined by thermogravimetric analysis (TGA), which is a deviation from OECD Guidelines for The Testing of Chemicals, 103, July 27 1995. The sample was dried under a nitrogen purge to remove water from the sample