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EC number: 200-500-0 | CAS number: 61-19-8
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 - 24 April 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- Adenosine phosphate
- EC Number:
- 200-500-0
- EC Name:
- Adenosine phosphate
- Cas Number:
- 61-19-8
- Molecular formula:
- C10H14N5O7P
- IUPAC Name:
- adenosine phosphate
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Test material form:
- solid: crystalline
- Remarks:
- crystalline powder
- Details on test material:
- Batch No: 11679700
Storage: at room temperature, protected from light
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Since the test item contains no lager particles, sieving < 2000 µm was not necessary and the test item was used as delivered.
Results and discussion
Particle sizeopen allclose all
- Key result
- Percentile:
- D10
- Mean:
- 3.6 µm
- St. dev.:
- 0.02
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D50
- Mean:
- 13.8 µm
- St. dev.:
- 0.1
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D90
- Mean:
- 174.3 µm
- St. dev.:
- 5.75
- Remarks on result:
- other: Average result calculated from the results of two test series
Any other information on results incl. tables
Visual Microscope Analysis
(1) under a microscope with 5x magnification agglomerates can be observed
(2) under a microscope with 20x magnification agglomerates can be observed
(3) under a microscope with 50x magnification, the test item consists of a mixture of cylindrical and spherical particles at lower particle sizes.
Particle Size Distribution
The test item shows a bimodal particle size distribution with two peaks at approx. 10 µm and 250 µm.
Test series 1:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 3.6 | 0.03 |
| D50 | 13.9 | 0.22 |
| D90 | 180.0 | 3.54 |
Test series 2:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 3.6 | 0.01 |
| D50 | 13.7 | 0.08 |
| D90 | 168.5 | 1.71 |
Applicant's summary and conclusion
- Conclusions:
- The test item Adenosine-5'-monophosphate (CAS 61-19-8) has a median particle size D50 = 13.8 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
- Executive summary:
The test item Adenosine-5'-monophosphate (AMP) (CAS 61 -19 -8) has a median particle size D50= 13.8 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
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