Registration Dossier
Registration Dossier
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EC number: 205-044-6 | CAS number: 131-92-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 10 female rats instead of 5 females and 5 males used
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-(10,15,16,17-tetrahydro-5,10,15,17-tetraoxo-5H-dinaphtho[2,3-a:2',3'-i]carbazole-4,9-diyl)bis(benzamide)
- EC Number:
- 205-044-6
- EC Name:
- N,N'-(10,15,16,17-tetrahydro-5,10,15,17-tetraoxo-5H-dinaphtho[2,3-a:2',3'-i]carbazole-4,9-diyl)bis(benzamide)
- Cas Number:
- 131-92-0
- Molecular formula:
- C42H23N3O6
- IUPAC Name:
- N,N'-(10,15,16,17-tetrahydro-5,10,15,17-tetraoxo-5H-dinaphtho[2,3-a:2',3'-i]carbazole-4,9-diyl)bis(benzamide)
- Test material form:
- solid
- Details on test material:
- Vat Brown 3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqua dest.
- Details on oral exposure:
- Application volume: 30mL/kg
- Doses:
- 3, 5, 7, 8 and 10 g/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 6 230 mg/kg bw
- Based on:
- test mat.
- Mortality:
- mortality occured within 3h to 1 day after application
- Clinical signs:
- sedation, rough fur
- Body weight:
- no data
- Gross pathology:
- no data
Any other information on results incl. tables
dose [g/kg bw] |
dead /treated animals |
3 |
1/10 |
5 |
3/10 |
7 |
5/10 |
8 |
7/10 |
| 10 | 9/10 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 (oral, gavage) for female wistar rates was determined to be 6230 mg/kg bw under the conditions of the test. The substance is not classifiable according to CLP criteria.
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