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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authoritative database.

Data source

Reference
Reference Type:
other: Authoritative database.
Title:
Acute oral toxicity study of Belotex PAD (CAS no: 88-38-0) in Rat.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
The acute oral toxicity test of 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid (CAS no: 88-38-0) in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name: 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid
InChI: 1S/C44H36N12O6S2/c57-63(58,59)37-27-35(49-43-53-39(45-31-13-5-1-6-14-31) 51-40(54-43)46-32-15-7-2-8-16-32)25-23-29 (37)21-22-30-24-26-36(28-38(30)64(60,61)62) 50-44-55-41(47-33-17-9-3-10-18-33)52-42(56-44)48-34-19-11-4-12-20-34 /h1-28H, (H,57,58,59)(H,60,61,62)(H3,45,46,49,51,53,54)(H3,47,48,50,52,55,56)/b22-21+
Smiles: S(c1cc(Nc2nc(Nc3ccccc3)nc(n2)Nc2ccccc2) ccc1\C=C\c1c(S(=O)(=O)O)cc(Nc2nc(Nc3ccccc3) nc(n2)Nc2ccccc2)cc1)(=O)(=O)O
- Name of test material: Belotex PAD
- Molecular formula: C44H36N12O6S2
- Molecular weight: 892.978 g/mol
- Substance type:Organic
Specific details on test material used for the study:
Name: 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid
InChI: 1S/C44H36N12O6S2/c57-63(58,59)37-27-35(49-43-53-39(45-31-13-5-1-6-14-31) 51-40(54-43)46-32-15-7-2-8-16-32)25-23-29 (37)21-22-30-24-26-36(28-38(30)64(60,61)62) 50-44-55-41(47-33-17-9-3-10-18-33)52-42(56-44)48-34-19-11-4-12-20-34 /h1-28H, (H,57,58,59)(H,60,61,62)(H3,45,46,49,51,53,54)(H3,47,48,50,52,55,56)/b22-21+
Smiles: S(c1cc(Nc2nc(Nc3ccccc3)nc(n2)Nc2ccccc2) ccc1\C=C\c1c(S(=O)(=O)O)cc(Nc2nc(Nc3ccccc3) nc(n2)Nc2ccccc2)cc1)(=O)(=O)O
- Name of test material: Belotex PAD
- Molecular formula: C44H36N12O6S2
- Molecular weight: 892.978 g/mol
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
not specified
Doses:
10000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed at 10000 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral LD50 value was considered to be >10000 mg/kg bw, when rats were treated with 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid (CAS no: 88-38-0) via oral route.
Executive summary:

Acute oral toxicity study of 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid (CAS no: 88-38-0) was conducted in rats at the concentration of 10000 mg/kg bw. No mortality was observed in treated rats at 10000 mg/kg bw. Therefore, LD50 was considered to be >10000 mg/kg bw, when rats were treated with4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid via oral route.