Registration Dossier
Registration Dossier
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EC number: 205-851-3 | CAS number: 156-38-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from the peer reviewed journal.
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The 50% growth inhibition concentration, IGC50, was determined for 4-Hydroxyphenylacetic Acid using the Probit Analysis routine in the Statistical Analysis System (SAS) software.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 4-Hydroxyphenylacetic Acid
- IUPAC name: 4-Hydroxyphenylacetic Acid
- Molecular formula: C8H8O3
- Molecular weight: 152.148 g/mol
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Tetrahymena pyriformis
- Details on inoculum:
- strain: GL-C
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Details on test conditions:
- 8–9 cell cycles in control cultures
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: IGC
- Effect conc.:
- 4 810 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: not toxic
- Conclusions:
- The 50% growth inhibition concentration, IGC50 to Tetrahymena pyriformis when exposed to 4-Hydroxyphenylacetic Acid for 48 hr is 4810 mg/L.
- Executive summary:
The toxicity values were from a population growth impairment test using the freshwater ciliate T. pyriformis (strain GL-C), performed.
Test conditions allow for 8–9 cell cycles in control cultures. Each definitive test replicate consisted of six to eight different concentrations with duplicate flasks of each concentration. Only replicates with control-absorbency values between 0.60 and 0.75 were used in the analyses.
The 50% growth inhibition concentration, IGC50, was determined for each compound using the Probit Analysis routine in the Statistical Analysis System (SAS) software.
The 50% growth inhibition concentration, IGC50 to Tetrahymena pyriformis when exposed to 4-Hydroxyphenylacetic Acid for 48 hr is 4810 mg/L.
Reference
Description of key information
The toxicity values were from a population growth impairment test using the freshwater ciliate T. pyriformis (strain GL-C), performed.
Test conditions allow for 8–9 cell cycles in control cultures. Each definitive test replicate consisted of six to eight different concentrations with duplicate flasks of each concentration. Only replicates with control-absorbency values between 0.60 and 0.75 were used in the analyses.
The 50% growth inhibition concentration, IGC50, was determined for each compound using the Probit Analysis routine in the Statistical Analysis System (SAS) software.
The 50% growth inhibition concentration, IGC50 to Tetrahymena pyriformis when exposed to 4-Hydroxyphenylacetic Acid for 48 hr is 4810 mg/L.Key value for chemical safety assessment
- EC50 for microorganisms:
- 4 810 mg/L
Additional information
The toxicity values were from a population growth impairment test using the freshwater ciliate T. pyriformis (strain GL-C), performed.
Test conditions allow for 8–9 cell cycles in control cultures. Each definitive test replicate consisted of six to eight different concentrations with duplicate flasks of each concentration. Only replicates with control-absorbency values between 0.60 and 0.75 were used in the analyses.
The 50% growth inhibition concentration, IGC50, was determined for each compound using the Probit Analysis routine in the Statistical Analysis System (SAS) software.
The 50% growth inhibition concentration, IGC50 to Tetrahymena pyriformis when exposed to 4-Hydroxyphenylacetic Acid for 48 hr is 4810 mg/L.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
