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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is peer-reviewed in the SIDS, non-GLP study which satisfies the guideline requirements
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study
Guideline:
other: Draft of the ASTM Comittee on Water quality: Proposed standard practice for conducting static acute toxicity tests on process wastewaters with Daphnia (1979) Draft 6, Personal correspondence.
GLP compliance:
no
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Analytical monitoring:
not specified
Details on sampling:
Details not provided
Vehicle:
not specified
Details on test solutions:
Details not provided
Test organisms (species):
Daphnia magna
Details on test organisms:
Details not provided
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
Details not provided
Hardness:
total hardness : 100 mg/L as CaCO3
Test temperature:
Details not provided
pH:
7.6
Dissolved oxygen:
Details not provided
Salinity:
Not applicable
Nominal and measured concentrations:
Nominal test substance concentrations: 5,000; 7,500; 10,000; 15,000, 20,000, 25,000; 40,0000 mg/L
Details on test conditions:
- 4 replicates were tested
- 250 mL Erlenmayer flasks containing 200 mL of test solution and five 1 -3 day old daphnids
Reference substance (positive control):
not specified
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
14 500 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: immobility
Remarks on result:
other: 12,116 - 17,353 mg/L
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
13 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: immobility
Remarks on result:
other: 10,330 - 16,360 mg/L
Details on results:
Details were tot provided
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
EC50 values were calculated by probit analysis.

No remarks

Validity criteria fulfilled:
not specified
Conclusions:
The 48-hour EC50 for trimethylolpropane was 13,000 mg/L.


Executive summary:

The 48-hr-acute toxicity of trimethylolpropane to Daphnia magna was studied under static conditions. Daphnids were exposed to the substance at nominal concentrations of 5,000; 7,500; 10,000; 15,000, 20,000, 25,000; 40,0000 mg/L. Immobilization was observed at 24 and 48h. The 48-hour EC50 was 13,000 mg/L (based on nominal concentrations).

This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.

Reference: Walton, J.R. and Davis, E.M., 1980

Description of key information

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
130 000 mg/L

Additional information

Assessment is by read-across to the source substance trimethylolpropane (CAS No: 77-99-6).