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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 15 March 2002 to 10 November 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: There is minor deviation from the recommended guideline but it does not affect the outcome of the study.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
in the preliminary test, the volume of water > 100 mL was not used, • i the definitive test was performed at 3°C ± 2°C instead of 5°C ± 0.5°C, and the water solubility was determined at 3°C, 20°C and 30°C.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
in the preliminary test, the volume of water > 100 mL was not used, • the definitive test was performed at 3°C ± 2°C instead of 5°C ± 0.5°C, and the water solubility was determined at 3°C, 20°C and 30°C.
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
586 - 708 g/L
Temp.:
30 °C
pH:
>= 5
Remarks on result:
other: CV=9%
Key result
Water solubility:
551 - 593 g/L
Temp.:
20 °C
pH:
>= 5
Remarks on result:
other: CV=4%
Key result
Water solubility:
478 - 524 g/L
Temp.:
3 °C
pH:
>= 5
Remarks on result:
other: CV=5%
Key result
Water solubility:
583 - 705 g/L
Temp.:
30 °C
pH:
>= 7
Remarks on result:
other: CV=9%
Key result
Water solubility:
545 - 599 g/L
Temp.:
20 °C
pH:
>= 7
Remarks on result:
other: CV=5%
Key result
Water solubility:
477 - 531 g/L
Temp.:
3 °C
pH:
>= 7
Remarks on result:
other: CV=5%
Key result
Water solubility:
588 - 698 g/L
Temp.:
30 °C
pH:
>= 9
Remarks on result:
other: CV=9%
Key result
Water solubility:
541 - 601 g/L
Temp.:
20 °C
pH:
>= 9
Remarks on result:
other: CV=5%
Key result
Water solubility:
466 - 510 g/L
Temp.:
3 °C
pH:
>= 9
Remarks on result:
other: CV=4%
Conclusions:
The result was as follows:
pH 5.0643 ± 57 g/L (CV = 9%) at 30.0°C ± 0.2°C, .572 ± 21 g/L (CV = 4%) at 20.0°C ± 0.2°C,501 ± 23 g/L (CV = 5%) at 3°C ± 2°C.
pH 7.0 .644 ± 61 g/L (CV = 9%) at 30.0°C ± 0.2°C, .572 ± 27 g/L (CV = 5%) at 20.0°C ± 0.2°C, .504 ± 27 g/L (CV = 5%) at 3°C ± 2°C.
pH 9.0 .643 ± 55 g/L (CV = 9%) at 30.0°C ± 0.2°C, 571 ± 30 g/L (CV = 5%) at 20.0°C ± 0.2°C, 488 ± 22 g/L (CV = 4%) at 3°C ± 2°C.

The resulting saturated solutions were colorless and basic.
Executive summary:

The aim of this study was the determination of the water solubility of the test material

The test procedure used was the EU Method A6 and the OECD guideline 105.

The method for analysis was the flask method.

The result was as follows:

The solubility in water was found to be:

pH 5.0

643 ± 57 g/L (CV = 9%) at 30.0°C ± 0.2°C, .

572 ± 21 g/L (CV = 4%) at 20.0°C ± 0.2°C,

501 ± 23 g/L (CV = 5%) at 3°C ± 2°C.

pH 7.0 .

644 ± 61 g/L (CV = 9%) at 30.0°C ± 0.2°C, .

572 ± 27 g/L (CV = 5%) at 20.0°C ± 0.2°C, .

504 ± 27 g/L (CV = 5%) at 3°C ± 2°C.

pH 9.0 .

643 ± 55 g/L (CV = 9%) at 30.0°C ± 0.2°C,

571 ± 30 g/L (CV = 5%) at 20.0°C ± 0.2°C,

488 ± 22 g/L (CV = 4%) at 3°C ± 2°C.

The resulting saturated solutions were colorless and basic.

Description of key information

Key study according to EU Method A6 and the OECD guideline 105.


The result was as follows:


The solubility in water was found to be:


pH 5.0


643 ± 57 g/L (CV = 9%) at 30.0°C ± 0.2°C, .


572 ± 21 g/L (CV = 4%) at 20.0°C ± 0.2°C,


501 ± 23 g/L (CV = 5%) at 3°C ± 2°C.


pH 7.0 .


644 ± 61 g/L (CV = 9%) at 30.0°C ± 0.2°C, .


572 ± 27 g/L (CV = 5%) at 20.0°C ± 0.2°C, .


504 ± 27 g/L (CV = 5%) at 3°C ± 2°C.


pH 9.0 .


643 ± 55 g/L (CV = 9%) at 30.0°C ± 0.2°C, .


571 ± 30 g/L (CV = 5%) at 20.0°C ± 0.2°C, .


488 ± 22 g/L (CV = 4%) at 3°C ± 2°C.


The resulting saturated solutions were colorless and basic.

Key value for chemical safety assessment

Water solubility:
572 g/L
at the temperature of:
20 °C

Additional information