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EC number: 215-403-9
CAS number: 1325-65-1
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 40290.
After epidermal induction, due to
orange-red discoloration produced by test substance, a possible erythema
reaction could not be determined.
Viability / mortality / macroscopic
findings: as there were no deaths during the treatment period, no
necropsies were performed.
Clical signs, systemic: no symptoms of
systemic toxicity were observed in the animals.
Body weight: 2 out of 10 animals of the
control group (nos. 325, 330) and 1 out of 20 animals of the test group
(no. 346) incidentally lost weight during the acclimatisation period. No
weight loss was observed during treatment period.
A guinea pig maximisation test was carried
out to assess the allergenic potential of the substance. Ten males were
used as control group and 20 males were used as test group.
the main test, a pretest was performed in order to identify a maximally
tolerated concentration of test article suitable for the induction phase
of the main study. In addition, a suitable non-irritant concentration of
test article, by the topical route of administration, was identified for
the challenge application.
pretest was performed by intradermal (0.1 ml/site, at concentrations of
1, 3 and 5 % of test article in bi-distilled water) and epidermal route
(5, 10, 15 and 25 % of test material in bi-distilled water).
Based on pretest findings:
application a 5 % test substance dilution in bi-distilled water was
25 % test substance in bi-distilled water was selected for the induction
application and 15 % test substance in bi-distilled water was selected
for the challenge application.
of the animals of the test group showed positive skin reactions
responding to a 5 % intradermal induction dose. Therefore, test
substance was considered as not skin sensitising.
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