Registration Dossier
Registration Dossier
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EC number: 201-474-3 | CAS number: 83-41-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: Literature (Handbook)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicological Evaluations: Potential Health Hazards of Existing Chemicals
- Author:
- Berufsgenossenschaft der chemischen Industrie
- Year:
- 1 995
- Bibliographic source:
- ISBN 3-540-59148-6; Springer-Verlag Berlin
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-nitro-o-xylene
- EC Number:
- 201-474-3
- EC Name:
- 3-nitro-o-xylene
- Cas Number:
- 83-41-0
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 1,2-dimethyl-3-nitrobenzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 4h
Results and discussion
In vivo
- Irritant / corrosive response data:
- 1 to 24 hours after removal of the patch, barely perceptible to clear localized erythema and barely perceptible to clear localized oedema occurred. All of the irritant effects had cleared up 72 hours after removal of the patch
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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