Registration Dossier

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics
Type of information:
other: written assessment
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A full toxicokinetic assessment of the substance is not deemed necessary. The toxicokinetic profile of this test substance has been addressed in a variety of studies since manufacture of the substance commenced in the 1950's, with detailed assessments throughout publically available literature being available. As such, it is deemed appropriate on animal welfare grounds to provide this as a written synopsis assessment only, rather than a definitive study. This is detailed below in "overall remarks".

Description of key information

Toxicokinetics, metabolism and distribution

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
100
Absorption rate - inhalation (%):
100

Additional information

A desktop assessment of Toxicokinetics, metabolism and distribution is undertaken. The substance is considered to be of low bioaccumulation potential.