Registration Dossier
Registration Dossier
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EC number: 229-043-5 | CAS number: 6407-78-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- REPORTS of the Scientific Committee on Cosmetology (seventh series)
- Author:
- European Commission (EC) - Scientific Committee on Cosmetology (SCC)
- Year:
- 1 988
- Bibliographic source:
- COMMISSION OF THE EUROPEAN COMMUNITIES; Brussels, Luxembourg, 1988.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study of chemical C.I. Pigment Red 3(CAS No: 2425-85-6) was conducted on abraded and non abraded skin of rabbits under occlusive condition to assess the skin irritancy of test chemical.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-(4-methyl-2-nitrophenylazo)-2-naphthol
- EC Number:
- 219-372-2
- EC Name:
- 1-(4-methyl-2-nitrophenylazo)-2-naphthol
- Cas Number:
- 2425-85-6
- Molecular formula:
- C17H13N3O3
- IUPAC Name:
- 1-(4-Methyl-2-nitrophenylazo)-2-naphthol
- Test material form:
- solid
- Details on test material:
- - Name of test material: C.I. Pigment Red 3
- Molecular formula: C17H13N3O3
- Molecular weight: 307.308 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c12c(\N=N\c3c(cc(C)cc3)[N+](=O)[O-])c(ccc1cccc2)O
- InChI: 1S/C17H13N3O3/c1-11-6-8-14(15(10-11)20(22)23)18-19-17-13-5-3-2-4-12(13)7-9-16(17)21/h2-10,21H,1H3/b19-18+
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: C.I. Pigment Red 3
- Molecular formula: C17H13N3O3
- Molecular weight: 307.308 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c12c(\N=N\c3c(cc(C)cc3)[N+](=O)[O-])c(ccc1cccc2)O
- InChI: 1S/C17H13N3O3/c1-11-6-8-14(15(10-11)20(22)23)18-19-17-13-5-3-2-4-12(13)7-9-16(17)21/h2-10,21H,1H3/b19-18+
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No Data Available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Abraded and non abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Amount : 500mg
concentration applied: 100% - Duration of treatment / exposure:
- No Data Available
- Observation period:
- No Data Available
- Number of animals:
- No Data Available
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Negative effects were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material C.I. Pigment Red 3(CAS No: 2425-85-6) was considered to be not irritating to the abraded and non abraded skin of rabbits under occlusive condition.
- Executive summary:
Skin irritation study of chemical C.I. Pigment Red 3(CAS No: 2425-85-6) was conducted on rabbits to assess its skin irritancy.
TheC.I. Pigment Red 3 was applied on abraded and non abraded skin of each rabbits under occlusive condition.
No indication of skin irritation was observed. Hence the chemical C.I. Pigment Red 3(CAS No: 2425-85-6)was considered to be not irritating to theabraded and non abraded skin of rabbits under occlusive condition.
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