Registration Dossier
Registration Dossier
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EC number: 267-234-5 | CAS number: 67827-72-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) in rat
- Author:
- RTECS
- Year:
- 2 017
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) on rats.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- 1-methoxy-2-methyl-4-nitrobenzene
- Cas Number:
- 99-53-6
- Molecular formula:
- C8H9NO3
- IUPAC Name:
- 1-methoxy-2-methyl-4-nitrobenzene
- Details on test material:
- - Name of test material (IUPAC name): 1-methoxy-2-methyl-4-nitrobenzene
- Common name: 2-Methyl-4-nitrophenol
- Molecular formula: C8H9NO3
- Molecular weight: 153.136 g/mol
- Smiles notation: c1(cc(c(O)cc1)C)[N+](=O)[O-]
- InChl: 1S/C7H7NO3/c1-5-4-6(8(10)11)2-3-7(5)9/h2-4,9H,1H3
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):2-Methyl-4-nitrophenol
- Molecular formula :C8H9NO3
- Molecular weight :153.136 g/mol
- Substance type:organic
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 390 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 390 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed at dose 390 mg/kg bw
- Mortality:
- 50% mortality was observed at dose 390 mg/kg bw in treated rats
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 390 mg/kg bw,when mouse was treated with 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) orally.
- Executive summary:
Acute oral toxicity study was done in mouse using test material 1-methoxy-2-methyl-4-nitrobenzene (99-53-6).50% mortality was observed at dose 390 mg/kg bw. Hence,LD50 value was considered to be 390 mg/kg bw,when mouse was treated with 1-methoxy-2-methyl-4-nitrobenzene (99-53-6) orally.
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