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EC number: 233-050-9
CAS number: 10025-99-7
Compared to controls, the test substance caused a 23-fold increase in
number of auricular lymph node (ALN) proliferating cells (ALN index =
22.8), and there was a 4-fold increase in global ALN cell yield per
animal (mean global ALN cell yield +/- SD, 16.9 +/- 3.7 vs 4.3 +/- 1.5
(x 1,000,000 cells), p<0.01). The response was said to be comparable to
that obtained following a single dose of the potent skin sensitiser
At lower concentrations of test compound [not specified and no further
details given], no such increase observed (ALN index <2); the vehicle
elicited an ALN index of <1.5 (i.e. reported as no reactivity).
The proliferative response detected in the ALN following skin exposure
to sodium hexachloroplatinate was said to provide suggestive evidence
for the predominant activation of CD4+ T lymphocytes.
In a study broadly comparable to the local lymph node assay (LLNA),
groups of 5 mice were subjected to local applications, on both ears, of
5% disodium hexachloroplatinate on each of 4 consecutive days. Around 48
hours after the last exposure, the auricular lymph nodes cells were
The test substance caused a 23-fold increase in number of ALN (auricular
lymph node) proliferating cells, and a 4 -fold increase in global ALN
cell yield per animal compared to vehicle controls. This response was
comparable to that seen in the positive control, indicating that
disodium hexachlorplatinate has skin sensitisation potential.
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