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EC number: 701-083-2
CAS number: -
In this study the potential of CAS No. :68512 -53 -8 (Batch ESDB01441)
to induce gene mutations at the HPRT locus in V 79 cells of the Chinese
hamster lung in vitro was investigated.
The test compound was dissolved in cell culture medium and tested at the
without S9 -mix: 10,50,1,00,250,1000,2500 and 5000 µg/ml
with S9 -mix: 10,50,1,00,250,1000,2500 and 5000µg/ml
The concentration ranges were based on the results of preliminary
testing for solubility and toxicity. Slight toxicity was observed with
and without metabolic activation at the higest concentration.
This GLP study was initiated on 14th Jan. 2002.
Up to the highest investigated dose the test compound induced no
relevant and reproducable increase in mutant colony numbers in two
Appropriate reference mutagens used as positive controls showed a
significant increase in mutant colonies, thus indicating the sensitivity
of the assay, and the efficacy of the S9-mix.
In conclusion, CAS No.:68512 -53 -8 did not induce gene mutations
in the HPRT-test with V79 Chinese hamster cells, both in the presence as
well as in the absence of a metabolic activation system, under the
experimental conditions described.
CAS No.:68512 -53 -8 is not mutagenic in this in vitro HPRT assay
with V79 Chinese hamster lung cells
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