Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-083-2
CAS number: -
Table1 Summary of opacity, permeability andin
MeanIn vitroIrritation Score1, 2
MEA Polyborate 1:1
using the negative control mean opacity and mean permeability values.
vitro irritancy score (IVIS) = mean opacity value + (15 x mean OD490value).
Screening for the eye irritancy potential of MEA Polyborate 1:3
using the Bovine Corneal Opacity and Permeability test (BCOP test).
This summary describes the ocular irritation properties of MEA
Polyborate 1:3 on an isolated bovine cornea. The possible ocular
irritancy of MEA Polyborate 1:3 was tested through topical application
for 10 ± 1 minutes.
Batch EU-01696 of MEA Polyborate 1:3 was a clear
colourlessliquidwith a purity of 68% salt in water. The test substance
was applied as it is (750 µl) directly on top of the corneas.
The negative control responses of the opacity and permeability
values were less than the upper limits of the laboratory historical
rangeindicating that the negative control did not induce irritancy on
the corneas.The meanin vitroirritancy score of the positive
control (10% (w/v) Benzalkonium Chloride) was 144 and was within the
historical positive control data range.It was therefore concluded that
the test conditions were adequate and that the test system functioned
MEA Polyborate 1:3 did notinduce ocular irritation through both
endpoints, resulting in a meanin vitroirritancy score of 0.0
after 10 minutes of treatment.
Finally, it is concluded that this test is valid and that MEA
Polyborate 1:3 is not severe irritant or corrosive in the Bovine Corneal
Opacity and Permeability test under the experimental conditions
described in the report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again