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Physical & Chemical properties

Water solubility

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Administrative data

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 February 2015 to 02 April 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
0 g/L
Temp.:
20 °C
pH:
5.7 - 5.9

Preliminary test

The preliminary estimate of the water solubility was <1.04 x 10-5 g/L at 20.0 ± 0.5 °C and at a pH of 5.8.

 

Definitive test

Typical chromatograms, details of mean total peak area for the standard and sample solutions (Table 3.10) and the calibration curve are attached.

 

Table 3.11: Concentration (g/L) of test item in the sample solutions

Sample Number

Time Shaken at

~ 30 °C (h)

Time Equilibrated at 20 °C (h)

Concentration (g/L)

Solution pH

1

24

24

5.11 x 10-5

5.7

2

48

24

5.57 x 10-5

5.8

3

72

24

4.92 x 10-5

5.9

 

Overall concentration: 5.20 x 10-5 g/L at 20.0 ± 0.5 °C

Conclusions:
The water solubility of the test item was assessed in accordance with OECD Guideline 105 and was determined to be 0.000052 g/L of solution at 20.0 ± 0.5 °C.
Executive summary:

GUIDELINE

The determination was carried out using a procedure designed to be compatible with Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995, and EU Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.

METHOD

Water solubility was determined using the flask method. Three measurements were performed at 24, 48 and 72 h, with duplicate analysis. Equilibrium was found to be reached from 24 h, and the mean result was retained.

CONCLUSION

The water solubility of the test item has been determined to be 5.20 x 10E-05 g/L of solution at 20.0 ± 0.5 °C.

Description of key information

 The water solubility of the test item was assessed in accordance with OECD Guideline 105 and was determined to be 0.000052 g/L of solution at 20.0 ± 0.5 °C.

Key value for chemical safety assessment

Water solubility:
0 g/L
at the temperature of:
20 °C

Additional information

GUIDELINE

The determination was carried out using a procedure designed to be compatible with Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995, and EU Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.

METHOD

Water solubility was determined using the flask method. Three measurements were performed at 24, 48 and 72 h, with duplicate analysis. Equilibrium was found to be reached from 24 h, and the mean result was retained.

CONCLUSION

The water solubility of the test item has been determined to be 5.20 x 10E-05 g/L of solution at 20.0 ± 0.5 °C.