2,2'-vinylenebis[5-methylbenzoxazole]

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Justification for type of information:

None

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not applicable

Principles of method if other than guideline:

None

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-vinylenebis[5-methylbenzoxazole]

EC Number:

213-866-1

EC Name:

2,2'-vinylenebis[5-methylbenzoxazole]

Cas Number:

1041-00-5

Molecular formula:

C18H14N2O2

IUPAC Name:

2,2'-vinylenebis[5-methylbenzoxazole]

Test material form:

solid: particulate/powder

Details on test material:

Identity FAT 65004/F TE
Batch 15060201 (China)
Purity determined in this study
Appearance
Smell
yellowish powder, solid at 20°C
neutral
pH-Value pH-value of a soln. of 2% (w/w) = 6.90
Expiration date August 25th, 2020
Storage to be stored at room-temperature

Specific details on test material used for the study:

None

Test animals

Species:

rat

Strain:

other: TIf:RAI

Sex:

male/female

Details on test animals or test system and environmental conditions:

The experiments were performed on healthy, young, random-bred rats of the Tif RAI strain. Their mean initial body weight was between 91 and 108 g. The animals had previously been acclimatized in our laboratories for at least 5 days to a constant room temperature of 22±1 °C, a relative humidity of 55±5% and 14 hours light/day. They were housed in groups of 5 in macrolon cages (Size 3). The animals were fed a standard diet of Nafag ad libitum and had free access of drinking water.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Remarks:

2%

Details on oral exposure:

Tgroups of 5 male and 5 female rats, after having been fasted overnight, were given various single doses of the compound, suspended in water by gavage.

Doses:

1000, 3000, 10000 and 15000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

Symptoms and mortality after administration were recorded during an observation period of 8 days.

Statistics:

Not specified

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 15 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred.

Clinical signs:

other: No symptoms were recorded.

Gross pathology:

Not specified

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The athe acute oral median lethal dose (LD50) of compound FAT 65004/B to rats is greater than 15000 mg/kg body weight.

Executive summary:

The acute oral toxicity potential of the test substance was evaluated in a study conducted with Tif:RAI strain rats. Groups of 5 male and 5 female rats, after having been fasted overnight, were given various single doses of the compound, suspended in water by gavage. The doses administered were 1000, 3000, 10000 and 15000 mg/kg bw. No symptoms were recorded and no deaths occurred. Hence, it was concluded that the acute oral median lethal dose (LD50) of compound FAT 65004/B to rats is greater than 15000 mg/kg body weight.