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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1964
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Pre-guideline and pre-GLP study. Only basic data given but considered sufficient for a weight of evidence (purity not reported, test system details not reported; body weight and gross pathology not reported).

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1964

Materials and methods

Principles of method if other than guideline:
Rats were given a single oral dose of test item and then observed for 14 days.
GLP compliance:
no
Remarks:
pre-GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-allyl-2-methoxyphenyl acetate
EC Number:
202-235-6
EC Name:
4-allyl-2-methoxyphenyl acetate
Cas Number:
93-28-7
Molecular formula:
C12H14O3
IUPAC Name:
4-allyl-2-methoxyphenyl acetate
Test material form:
liquid

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: rats: 180-350 g
- Fasting period before study: 18 hours
- Diet, ad libitum
- Water, ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Not reported
Doses:
No data
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: The rats were observed until the survivors had returned to normal in appearance and weight
Statistics:
LD50s were computed by the method of Litchfield and Wilcoxon (1949).

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 670 mg/kg bw
Based on:
test mat.
95% CL:
>= 1 265 - <= 2 200
Mortality:
Animals died within 4 hours to 2 days after treatment.
Clinical signs:
Rough fur, depression
Body weight:
No data
Gross pathology:
No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Under the test conditions, test material is classified Category 4 (H302: Harmful if swallowed) according to the Regulation (EC) No. 1272/2008 and of the GHS as the LD50 value is comprised between 300 and 2000 mg/kg bw.
Executive summary:

In an acute oral toxicity study, rats (5/sex/dose) were administered the test substance by gavage with a stomach tube. Animals were then observed for mortality and clinical signs for 14 days.

Deaths occurred between 4 hours and 2 days and clinical signs were reported to be rough fur and depression.

Combined oral LD50 = 1670 mg/kg bw (95% CL 1265 -2200 mg/kg bw).

 

Under the test conditions, test material is classified Category 4 (H302: Harmful if swallowed) according to the Regulation (EC) No. 1272/2008 and of the GHS as the LD50 value is comprised between 300 and 2000 mg/kg bw.

This study is considered as sufficiently reliable in a weight of evidence approach for the purpose of acute oral toxicity endpoint.