Registration Dossier
Registration Dossier
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EC number: 207-529-8 | CAS number: 479-27-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- 5 male and 5 female Wistar rats were treated occlusively with a single application of 2000 mg/kg bw of 1,8-naphthylendiamine. The animals were observed for mortality, body weights and clinical signs through day 14. Gross pathological examinations were done on all animals sacrificed at the end of study. Necropsy records were prepared for all animals.
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,8-naphthylenediamine
- EC Number:
- 207-529-8
- EC Name:
- 1,8-naphthylenediamine
- Cas Number:
- 479-27-6
- Molecular formula:
- C10H10N2
- IUPAC Name:
- naphthalene-1,8-diamine
- Details on test material:
- purity: 99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 1,2-propandiole
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female rats were applied a dose of 2000 mg/kg bw
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No signs of systemic poisoning were observed and no skin changes were seen. Two male rats and one female rats showed a slight decrease in body weight during the 1st and 2nd study week, respectively. No deaths occured. None of the animals sacrificed at the end of the 14-day observation period showed any noticable gross pathological findings.
Applicant's summary and conclusion
- Executive summary:
Five male and five female Wistar rats were treated occlusively with a single application of 2000 mg/kg bw of 1,8-naphthylendiamine. The animals were observed for mortality, body weights and clinical signs through day 14. Gross pathological examinations were done on all animals sacrificed at the end of study. Necropsy records were prepared for all animals.
No death occured (LD50 > 2000 mg/kg bw). No signs of systemic poisoning were observed and no skin changes were seen. Two male rats and one female rats showed a slight decrease in body weight during the 1st and 2nd study week, respectively. None of the animals sacrificed at the end of the 14-day observation period showed any noticable gross pathological findings.
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