Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Prediction of Skin Irritation from Organic Chemicals Using Membrane-Interaction QSAR Analysis
Author:
Kiran Kodithala, A. J. Hopfinger, Edward D. Thompson, and Michael K. Robinson
Year:
2002
Bibliographic source:
TOXICOLOGICAL SCIENCES 66, 336–346 (2002)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation study was conducted on rabbits to determine the adverse effects caused by the chemical 2-CHLORO-4-NITROPHENOL (CAS No:619-08-9) by performing Draize test.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloro-4-nitrophenol
EC Number:
210-578-8
EC Name:
2-chloro-4-nitrophenol
Cas Number:
619-08-9
Molecular formula:
C6H4ClNO3
IUPAC Name:
2-chloro-4-nitrophenol
Details on test material:
- IUPAC Name: 2-chloro-4-nitrophenol
- Common Name: Nitrofungin
- Mol. formula: C6H4ClNO3
- Molecular Weight: 173.555 g/mol
- Smiles: c1(cc(c(O)cc1)Cl)[N+](=O)[O-]
- InChI: 1S/C6H4ClNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H
Specific details on test material used for the study:
- IUPAC Name: 2-chloro-4-nitrophenol
- Common Name: Nitrofungin
- Mol. formula: C6H4ClNO3
- Molecular Weight: 173.555 g/mol
- Smiles: c1(cc(c(O)cc1)Cl)[N+](=O)[O-]
- InChI: 1S/C6H4ClNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period (in vivo):
No data available
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Score:
34
Max. score:
110
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
moderate irriation was observed in treated rabbits.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The chemical produced PII value of 34 out of maximum score of 110 when the chemical installed into the eye of each rabbit.

Therefore 2-CHLORO-4-NITROPHENOL (619-08-9) was considered to be Moderately irritating to the eye of rabbits.
Executive summary:

An eye irritation study was conducted on rabbits to determine the adverse effects caused by the chemical 2-CHLORO-4-NITROPHENOL (619-08-9) by performing Draize test.

 

The chemical produced PII value of 34 out of maximum score of 110 when the chemical installed into the eye of each rabbit.

 

Therefore 2-CHLORO-4-NITROPHENOL (619-08-9) was considered to be Moderately irritating to the eye of rabbits.